Metamorphic proteins: the Janus proteins of structural biology

a structural survey of the polish posters

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Regulation of Janus kinases by SOCS proteins.

JAKs (Janus kinases) are essential mediators of almost all biological signalling events initiated by haemopoietic and immune cytokines. However, aberrant and/or prolonged JAK-induced signalling is detrimental and can give rise to a number of inflammatory and proliferative pathologies. For this reason, the tyrosine kinase activity of the JAKs is carefully regulated at a number of different level...

Knotted proteins: A tangled tale of Structural Biology

Knotted proteins have their native structures arranged in the form of an open knot. In the last ten years researchers have been making significant efforts to reveal their folding mechanism and understand which functional advantage(s) knots convey to their carriers. Molecular simulations have been playing a fundamental role in this endeavor, and early computational predictions about the knotting...

Knowledge discovery in molecular biology: Identifying structural regularities in proteins

A study of the Electrophoretic Pattern of the serum Proteins